Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer
نویسندگان
چکیده
After 25 years of its discovery in the rat brain, d-serine is a recognized modulator of synaptic plasticity and cognitive processes through its actions on the NMDA-glutamate receptor. Importantly, cognitive impairment is a core feature of conditions, such as schizophrenia, Alzheimer's disease, depression, and aging, and is associated to disturbances in NMDA-glutamate receptors. The d-serine pathway has been associated with cognitive deficits and these conditions, and, for this reason, d-serine signaling is subject of intense research to probe its role in aiding diagnosis and therapy. Nevertheless, this has not resulted in new therapies being incorporated into clinical practice. Therefore, in this review we will address many questions that need to be solved by future studies, regarding d-serine pharmacokinetics, possible side effects, other strategies to modulate its levels, and combination with other therapies to increase its efficacy.
منابع مشابه
VGB3 Induces Apoptosis by Inhibiting Phosphorylation of NF-κB p65 at Serine 536 in the Human Umbilical Vein Endothelial Cells
Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...
متن کاملEvaluating the Efficacy of Vitamin D Add-on Therapy on Treatment of Positive, Negative and Cognitive Symptoms in Patients with Chronic Schizophrenia; A Double Blind Clinical Trial
Background: Vitamin D can be effective in treating some symptoms of schizophrenia, and with better control of vitamin D levels and supplementation, there is a potential for reducing this disease. But due to small number of studies, more studies are needed in this area. The aim of this study was to determine the efficacy of vitamin D as an adjunct to the positive, negative, and cognitive symptom...
متن کاملApplication of environmental bacteria as potential methods of azo dye degradation systems
BACKGROUND AND OBJECTIVES:The objective of this study isto present a description of the main characteristics of azo dyes and the different treatment methods used to remove them from water. There is a special emphasis given to the benefits associated with biological treatment, predominantly those related to the use of bacteria, which has to do with its competitive advantages ove...
متن کاملIn Vitro Release Studies of Enoxaparin in Nanoparticle form and Enterically Coated Tablets Containing Surfactants
In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...
متن کاملP 139: Curcumin anti-Inflammatory Effect in Neuroinflammatory Disorders: Prospective and Challenges
Curcumin is a hydrophobic polyphenol and major bioactive component of turmeric with known anti-inflammatory, neurogenesis, antioxidant, and anti-carcinogenic effect. Curcumin antagonizes many steps in the inflammatory cascade, including Inhibition of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), activator protein-1 transcription and iNOS (induced Nitric oxide syn...
متن کامل